Should You Bank Stem Cells for Personal Use?
Patients should be aware that there are unscrupulous stem cell clinics that make false promises about stem cell therapies and promote banking stem cells for years, or even decades, for unproven future uses, if they can even be used at all. Additionally, any offered “treatments” could cause physical and financial harm. Typically, there are yearly storage fees at private banks, and this storage of cells for a potential treatment that has not yet been proven safe or effective can be costly.
At this time, it is not recommended to bank these stem cells:
Blood Stem Cells for Unproven Purposes
There are companies that promote banking adult blood stem cells for new, experimental personal uses. These companies claim that stem cells can be frozen when you are young and used later in life for "rejuvenation," or for “treatments” claiming to restore youthfulness and vitality. Currently, there is no evidence, however, that such a “treatment” would be effective in humans. Recently, the U.S. Food and Drug Administration issued a statement warning that infusing young blood into an older individual has no proven clinical benefit, and that it might in fact cause harm. More research is needed to determine whether transplanting young blood stem cells or blood products into older people can be safe and efficacious.
Consumers should be aware that banking adult blood stem cells for an indeterminate time can be expensive and that unproven stem cell treatments carry medical risk.
Mesenchymal Stromal Cells (MSCs)
A growing number of clinics and online companies advertise the use of mesenchymal stromal or stem cells (MSCs) for myriad unproven stem cell treatments. Companies try to convince consumers that they should collect and freeze these cells to have on hand to treat a long list of potential future diseases.
While legitimate mesenchymal stem cells were first discovered in bone marrow through rigorous scientific study, the cells that are typically marketed by clinics that promote unproven or unapproved “treatments” are a collection of mixed and undefined cells from a patient’s blood, fat, or bone marrow. These cells are marketed for “stem cell” or “MSC” therapies, but the biological properties and therapeutic potential of these uncharacterized cells is unknown, and claims of therapeutic benefit are not supported by sound science. Directly injecting these ill-defined cells into patients is currently controversial and requires further study.
Mesenchymal stem cells also have been reported to be isolated from other tissues, such as dental pulp, amniotic fluid, and cord blood. Some of these cells are thought to have stem cell properties and currently are being studied and may, at some point in the future, have application for disorders. However, there is no known benefit that currently has been identified.
There are multiple legitimate clinical trials underway testing the benefits of rigorously characterized MSCs to treat various diseases and conditions, but it is too early to know if there will be a scientifically proven therapeutic benefit.
Before banking any tissues or cells for a potential future MSC therapy, you should talk to a board certified and licensed physician who is unaffiliated with the stem cell bank or clinic, and is knowledgeable about the patient’s condition and the science behind the clinical application of stem cells. Banking these cells, and the treatments offered, can be expensive and there is little to no evidence to date to indicate that they are beneficial. In fact, in some cases they may cause harm.
T Cells
T cells are a type of immune cell that are being developed into a cancer therapy that shows great promise in treating various types of the disease. T cells can be collected from a patient and engineered to specifically attack cancer cells, while leaving other cells in the body unharmed. This technology is called chimeric antigen receptor T-cell (CAR-T) therapy. Several CAR-T therapies are approved to treat certain kinds of blood cancers, such as leukemia and lymphoma, in multiple countries and regions around the world.
Some companies are freezing patient T cells for potential future therapeutic use. These companies are making unfounded promises and are offering commercial services that are not fully developed. Additionally, the chances of acquiring one of the types of cancer that can be treated is low.
The International Society for Cell and Gene Therapy recently issued a statement warning patients against banking T cells for potential future use.
Before You Bank
When evaluating any potential therapeutic intervention, you should ask questions and ensure to the extent possible that the treatment has been evaluated in an approved clinical trial, and that claims were tested through rigorous evidence-based science. Whether or not to donate or store stem cells for medical purposes is a personal decision, and you should always consult your doctor or a trusted medical professional.
If you are considering saving stem cells for a potential future stem cell therapy, refer to Nine Things to Know About Stem Cell Therapies to help inform your decision. If you are concerned that a stem cell clinic is providing unproven or unapproved stem cell treatments, you can refer to the How to Report False Marketing Claims and Adverse Events from Clinics Offering Unapproved Stem Cell “Therapies” webpage.
