Leer en: Español

Stem Cells in Focus

  • CRISPR, CAR-T, and Cancer

    Oct 27, 2017
    Researchers around the world have long sought effective treatments for cancer, and are now seeing therapeutic benefit with a new treatment, which is demonstrating better than imagined success in patients with blood cancer.
    Full story

  • Organoids: Advancing Regenerative Medicine

    Oct 03, 2017
    A patient’s fate may lie within a single cell. Therapeutic fate, that is. Scientists can pluck a lone cell, or just a few, out of a patient’s body, grow them in a petri dish, and coax them to form so-called organoids, three-dimensional miniature versions of the original tissue or organ that can be grown indefinitely in the lab.
    Full story

  • Advocates: Moving the Field Forward in Many Ways

    Aug 11, 2017
    The progress and outcomes of new treatments are important to us all, but arguably no one is more invested in the discovery of new therapies than patient advocate groups. Made up of passionate individuals who voluntarily organize to advocate on behalf of those with a particular disease or disorder, these ‘disease advocates’ dedicate their lives to bringing positive changes for others, sometimes including their families and themselves.
    Full story

  • Connecting Genetics and Heart Disease

    Aug 04, 2017
    Scientists and clinicians have long suspected and recently confirmed that a person’s genetic makeup contributes to the likelihood of their having a heart attack. However, there has remained a gap between our knowledge of genetic indicators and medicine; a gap that Dr. Chad Cowan, of Harvard University, is trying to bridge with stem cell research.
    Full story

  • Making Sense of Disease – In a Dish

    May 01, 2017
    Stem cell research is revolutionizing the way scientists study human disease in many ways. One of the most fascinating, is through the creation of human “diseases in a dish,” which are giving scientists a better way to study disease biology and test new drugs. Read how Dr. Kevin Eggan from the Harvard Stem Cell Institute is using this technology to better understand diseases such as amyotrophic lateral sclerosis (ALS) and schizophrenia.
    Full story

  • Exploring Endogenous Heart Repair and Regeneration

    Apr 17, 2017
    For the millions of people who suffer from heart attacks every year, the aftereffects are literally scarring. When the heart muscle dies from lack of blood, it is replaced by scar tissue, since the heart has very little regenerative capacity. This grim prospect is what stem cell scientists, like Dr. Deepak Srivastava, Director of Cardiovascular Disease and the Stem Cell Center at the Gladstone Institutes in San Francisco, are hoping to change.
    Full story

  • Introducing "Stem Cells in Focus"

    Apr 17, 2017
    Full story

  • Stem Cells May Be Key to Curing Retinal Disease

    Apr 17, 2017
    A team of UK stem cell scientists, led by Dr. Robin Ali from UCL Institute of Ophthalmology in London, has developed a new strategy for repairing the retina by transplanting photoreceptor cells generated in the laboratory from embryonic stem cells. There is a good precedent for using stem cell therapy to repair eye damage. Transplanting corneal stem cells to repair chemical burns of the cornea has been very successful in restoring vision. But the retina – a multi-layered neural network – is a much more complicated structure, so repairing it poses greater challenges.
    Full story

  • Ramping up Discovery with Kidney Organoids

    Apr 17, 2017
    Although they conjure up images of science fiction, organoids are actually the quirky new name for mini, lab-grown models of human organs. Scientists are using pluripotent stem cells – the master cells that make any cell in the body – to create small buds of brain, thymus, liver, intestine, eye or kidney tissue that replicate some of the functions we find in these organs.
    Full story

  • October 8 is Stem Cell Awareness Day

    Apr 17, 2017
    The ISSCR celebrates Stem Cell Awareness Day on October 8 with a Stem Cells in Focus webcast entitled “The Science of Regenerative Medicine,” presented by PhD candidate Ben Paylor of the Canadian Stem Cell Network. The webinar will explore the basics of stem cell biology and will include three StemCellShorts*, voiced by stem cell experts Drs. Jim Till, Janet Rossant and Mick Bhatia, as well as a question and answer period.
    Full story

  • Q&A: Stem Cells, Regenerative Medicine and Veterans

    Apr 17, 2017
    This week, nations around the world recognize Remembrance Day and Veterans Day. The ISSCR is proud of the role stem cell research is playing in advancing the field of regenerative medicine, which stands to benefit wounded servicemen and women. Dr. Anthony Atala, director of Wake Forest Institute for Regenerative Medicine, North Carolina, U.S.A., leads the consortium of researchers that make up the Armed Forces Institute of Regenerative Medicine (AFIRM). We spoke with him about the organization, which is working to develop advanced treatment options.
    Full story

  • Malaria-in-a-Dish Paves the Way for Better Treatments

    Apr 17, 2017
    Massachusetts Institute of Technology (MIT) researchers have discovered a new way to model malaria using stem cells in a petri dish, which will allow them to test potential antimalarial drugs and vaccines.
    Full story

  • Introducing A Closer Look at Stem Cells

    Apr 17, 2017
    Today, we welcome you to the blog’s new home, the expanded Closer Look at Stem Cells website (www.closerlookatstemcells.org). The website is a perfect complement to the “Stem Cells in Focus” blog, housing informational pages on basic stem cell biology, the process by which science becomes medicine, clinical trials and the use of stem cells in understanding and potentially treating specific health conditions.
    Full story

  • What to Consider: Human Genome Germline Modification

    Apr 17, 2017
    In the past few days, you may have heard about new research describing the editing of the DNA sequence in human embryos. This new research raises critical scientific, social, legal and ethical questions to be addressed by all of us.
    Full story

  • Newly Discovered STAP Cells Explained

    Apr 17, 2017
    You may have heard the news this week about exciting new developments in the field of stem cell research, published in the January 30 issue of Nature. A Japanese scientist, Dr. Haruko Obokata, and her colleagues demonstrated a new way to reprogram specialized stem cells from a newborn mouse to a “pluripotent” state; which is to say, the cells gained the ability to turn into any sort of cell in the body, much the same way embryonic stem cells can. Learn more about this discovery and its potential implications.
    Full story

  • Stimulating The Body's Stem Cells to Treat Multiple Sclerosis

    Apr 17, 2017
    What if, in this dawning era of regenerative medicine, we could help the body heal itself? Not by replacing diseased or damaged cells, as is so often the paradigm in this field, but by stimulating the stem cells already present in a given tissue to differentiate and then repair the damage. No, this isn’t science fiction, like using one of Dr. McCoy’s futuristic devices from Star Trek to heal the injured Captain Kirk. This approach is now being assessed as a potential treatment for multiple sclerosis.
    Full story

  • An Exciting Strategy for Treating Sickle Cell Disease with Stem Cells

    Apr 17, 2017
    Stem cell researchers are getting closer to a new treatment for sickle cell disease, moving promising laboratory research into human clinical trials. Millions of people worldwide suffer from this hereditary disease.
    Full story

  • Public Symposium: Stem Cells and the Aging Brain

    Apr 17, 2017
    At the ISSCR public symposium in Stockholm, stem cell scientists from Germany, Sweden and the U.S. will explore during a moderated panel discussion the role of stem cells in the brain during our lives from development and through adulthood. Panelists will discuss how scientists are investigating what happens to these cells as we age, how this knowledge is being used to guide new strategies to boost brain health and to develop therapies utilizing stem cells to treat diseases of the brain.
    Full story

  • Modeling Human Biology and Organoids: A Big Impact from a Miniature Tissue

    Apr 17, 2017
    Organoids, or miniature organs, are a relatively new model system that has emerged from stem cell research and are making a big impact. These laboratory-grown, three-dimensional, mini-organs are microscopically small and are started from stem cells. Within a specialized growth environment, the stem cells, either adult or embryonic, depending on the tissue needed, are stimulated to grow and specialize into specific types of organoids. Although they are not exact replicas of the adult organ, they do replicate many aspects and thus give us a model of human development that we would not otherwise have.
    Full story

  • Stem Cell Research: Promise, Progress & Hype

    Apr 17, 2017
    Summary of a panel discussion at the recent annual meeting of the International Society of Stem Cell Research in Stockholm, featuring international experts discussing the complex issues surrounding the sale and marketing of experimental stem cell treatments.
    Full story

  • The Importance of Professional Guidelines

    Apr 17, 2017
    Professional guidelines provide a practical and ethical framework for decision making and instill a sense of responsibility and accountability. Learn more about the ISSCR's guidelines for stem cell research and clinical translation.
    Full story

  • Stem Cells Need Sleep, Too

    Apr 17, 2017
    Sleep is important for our body. With modest sleep deprivation it can be a struggle to function at our highest level and long term sleep deprivation, or disruption, can have significant health effects. It turns out that your sleep deprivation may also impact others…....if you are donating your hematopoietic stem cells.
    Full story

  • Modeling the development and disease of the human enteric nervous system takes guts… and stem cells

    Apr 17, 2017
    Question: What part of the nervous system has over 500 million neurons - the cells that transmit electrical or chemical signals throughout the nervous system and beyond - and regulates important bodily functions? Sounds like the brain, right? What if you knew that this part of the nervous system also spans approximately 30 feet in an average adult? That’s right, it’s the enteric nervous system (ENS). Never heard of it?
    Full story

  • ISSCR’s Stem Cell Guidelines: A Commitment to Patients and the Public

    Apr 17, 2017
    Stem cell science is advancing at a pace greater than ever before, and researchers are making significant discoveries toward medical therapies to treat diseases and injuries - many of which currently have no cure. In May 2016, the ISSCR developed guidelines to help protect the integrity of stem cell research and assure the public that it will proceed efficiently and remain responsive to public interests.
    Full story

  • Celebrating Stem Cell Awareness Day – October 12

    Apr 17, 2017
    The ISSCR joins organizations and individuals around the world in celebrating the cells that are the building blocks of life: stem cells. Unlike other cell types, stem cells are unspecialized cells uniquely capable of making copies of themselves (self-renewing), differentiating into specialized cell types, and helping to maintain some tissues in the human body.
    Full story

  • Stem Cell Soup – The Importance of Knowing What Is In It

    Apr 17, 2017
    “I don’t even know what’s in the soup,” was the shocking quote from the founder of a chain of clinics highlighted in a recent Associated Press article about the increasing prevalence of clinics offering unproven stem cell therapies. The “soup” referred to the mixture of cells and fluid he extracted from a patient’s fat for re-injection into the same patient’s knees, one of many “stem cell” procedures being tried for more than 20 diseases and conditions.
    Full story

  • A CRISPR Method For Gene Editing: A Biomedical Breakthrough From a “Germ”

    Apr 17, 2017
    Bacteria. What do you think of when you hear this word? “Germs,” “antibiotics,” or “bleach” may come to mind, depending on the context. What about “powerhouse of scientific discovery?” That’s a string of words, but one that accurately describes the impact this single-celled organism is having on stem cell biology and human health.
    Full story

  • Stem Cell Year-in-Review 2016

    Apr 17, 2017
    If we picked one word to define the past year in the stem cell field, it would have to be ‘therapy.’ While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics using unproven stem cell “therapies,” and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial replacement therapy (MRT).
    Full story

  • Chimeras: From Mythology to the Lab

    Apr 17, 2017
    In Greek mythology, the chimera is often described and depicted as a monster, as in this image, that represents impending disaster. While chimeras in Greek literature are fictional and symbolic, the concept of chimeras in science, simply defined as an organism made of cells from two organisms, are real, and they represent scientific progress and its potential to impact human health.
    Full story

  • Stem Cells and the Aging Brain

    Apr 17, 2017
    Summary of a panel discussion on stem cells and the aging brain involving a world-leading grouping of international stem cell scientists.
    Full story

  • Hematopoietic Stem Cells: a New Transplant Paradigm for Multiple Sclerosis?

    Apr 17, 2017
    For years now, bone marrow transplants have been used to treat patients with leukemia and other blood disorders. The hematopoietic (blood-forming) stem cells present in bone marrow can restore a patient’s blood system after it has been devastated by chemotherapy or radiation. This same approach is now being tested in clinical trials for people with multiple sclerosis (MS) and other autoimmune diseases in the hope that providing brand new blood cells will reset the immune system to a healthy state.
    Full story

  • Bringing Focus to Stem Cell Treatment for Eye Disease

    Apr 17, 2017
    Several eye diseases are considered excellent candidates for stem cell therapy. In particular, widespread ocular diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), as well as a genetic condition called Stargardt’s macular dystrophy (STGD) that afflicts young people, are all potential disease targets for therapeutic approaches.
    Full story

  • Stem Cell Therapies: Are We Blinded by Perception or Focused on Reality?

    Apr 17, 2017
    Is there a stem cell therapy for [insert disease here]? The question arises nearly every day and it is not surprising given the abundance of articles and advertisements promoting the use of “stem cell treatments” for a staggering number of diseases and injuries. A quick search of the internet brings up a long list of clinics offering what appear to be stem cell solutions for a wide variety of medical problems.
    Full story

  • Connecting Genetics and Heart Disease

    Aug 04, 2014
    Scientists and clinicians have long suspected and recently confirmed that a person’s genetic makeup contributes to the likelihood of their having a heart attack. However, there has remained a gap between our knowledge of genetic indicators and medicine; a gap that Dr. Chad Cowan, of Harvard University, is trying to bridge with stem cell research.
    Full story

  • Exploring Endogenous Heart Repair and Regeneration

    Feb 14, 2014
    For the millions of people who suffer from heart attacks every year, the aftereffects are literally scarring. When the heart muscle dies from lack of blood, it is replaced by scar tissue, since the heart has very little regenerative capacity. This grim prospect is what stem cell scientists, like Dr. Deepak Srivastava, Director of Cardiovascular Disease and the Stem Cell Center at the Gladstone Institutes in San Francisco, are hoping to change.
    Full story

  • Introducing "Stem Cells in Focus"

    Jan 16, 2014
    Full story